BioAbsorb
Together they are designed to:
- Amplify glucose disposal and insulin sensitivity through dual AMPK activation and GLUT-4 translocation.
- Improve lipid and endothelial health by supporting healthy LDL-C, blood pressure and vascular function.
- Enhance mitochondrial energy production via coenzyme forms of vitamins B₁, B₂, B₅ and B₆.
- Maintain optimal one-carbon methylation and homocysteine balance with methyl-folate and methyl-cobalamin.
These complementary mechanisms make BioAbsorb a promising research candidate for studies of metabolic syndrome, cardiometabolic wellness and healthy aging.
BioAbsorb Ingredients (per capsule)
| Ingredient | Dose | Key Actions |
| Metformin | 125 mg | AMPK activation; insulin‐sensitizing & glucose-lowering [1] |
| DihydroBerberine | 125 mg | Highly absorbable berberine metabolite; improves glycemia & lipids [2] |
| Vitamin B₁ (Thiamin) | 12.5 mg | Pyruvate‐dehydrogenase cofactor; rescues endothelial dysfunction [3] |
| Vitamin B₂ (Riboflavin) | 12.5 mg | FAD precursor; lowers blood pressure in MTHFR-677TT carriers [4] |
| Vitamin B₅ (Pantethine) | 12.5 mg | CoA precursor; reduces LDL-C & non-HDL-C [5] |
| Vitamin B₆ (Pyridoxal-5-Phosphate) | 17.5 mg | PLP coenzyme; decreases plasma homocysteine [6] |
| Vitamin B₉ (Methyl-folate) | 200 mcg | Active folate; supports methylation & homocysteine control [7] |
| Vitamin B₁₂ (Methyl-cobalamin) | 50 mcg | Active B₁₂; neuroprotective, improves nerve conduction [8] |
Research Areas
- Glucose Disposal & Insulin Sensitivity
- Lipid & Cardiovascular Support
- Mitochondrial Energy Metabolism
- Methylation & Homocysteine Management
- Neuroprotection & Peripheral Nerve Health
Glucose Disposal & Insulin Sensitivity
Metformin activates hepatic and skeletal-muscle AMPK, suppressing gluconeogenesis and potentiating insulin-stimulated glucose uptake [1] . Dihydroberberine, a reduced berberine metabolite with far superior intestinal absorption, demonstrated greater area-under-the-curve exposure and produced acute reductions in post-prandial glucose in a randomized crossover pilot trial [2] .
Lipid & Endothelial Support
Pantethine (vitamin B₅ derivative) lowered total and LDL cholesterol by 11 % over 16 weeks in a triple-blinded, diet-controlled trial [5] . Low-dose thiamine reversed hyperglycemia-induced endothelial cell dysfunction in vitro, restoring migration capacity and reducing von Willebrand factor secretion [3] . Riboflavin supplementation (1.6 mg day⁻¹) produced clinically meaningful blood-pressure reductions in treated hypertensives carrying the MTHFR 677TT polymorphism [4] .
Methylation & Homocysteine Management
In a randomized controlled trial, combined methyl-folate (5-MTHF), PLP and methyl-cobalamin lowered plasma homocysteine by 30 % and LDL-C by 7.5 % after six months in adults with MTHFR/MTR/MTRR polymorphisms [7] . Independent PLP supplementation has likewise been shown to cut homocysteine while enhancing antioxidant capacity in postsurgical patients [6] .
Neuroprotection & Nerve Health
A 2020 systematic review and meta-analysis of randomized trials found that mecobalamin (methyl-B₁₂) significantly improved nerve-conduction velocity and overall clinical response in peripheral neuropathy, with a favorable safety profile [8] .
References
- Zhou G et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001;108:1167-1174. https://pubmed.ncbi.nlm.nih.gov/11602624/
- Moon JM et al. Absorption kinetics of berberine and dihydroberberine and their impact on glycemia. Nutrients. 2022;14(1):124. https://pubmed.ncbi.nlm.nih.gov/35010998/
- Ascher E et al. Thiamine reverses hyperglycemia-induced dysfunction in cultured endothelial cells. Surgery. 2001;130:851-858. https://pubmed.ncbi.nlm.nih.gov/11685195/
- Wilson CP et al. Blood pressure in hypertensive individuals with the MTHFR 677TT genotype is responsive to riboflavin: targeted randomized trial. Hypertension. 2013;61:1302-1308. https://pubmed.ncbi.nlm.nih.gov/23608654/
- Evans M et al. Pantethine favorably alters LDL and non-HDL cholesterol in low-to-moderate risk subjects. Vasc Health Risk Manag. 2014;10:89-100. https://pubmed.ncbi.nlm.nih.gov/24600231/
- Cheng SB et al. Vitamin B-6 supplementation reduces plasma homocysteine in hepatocellular-carcinoma patients after resection. Biomed Res Int. 2016;2016:7658981. https://pubmed.ncbi.nlm.nih.gov/27051670/
- Pokushalov E et al. Methylfolate, PLP and methylcobalamin supplementation lowers homocysteine and LDL-C: randomized controlled trial. Nutrients. 2024;16:1550. https://pubmed.ncbi.nlm.nih.gov/38892484/
- Sawangjit R et al. Efficacy and safety of mecobalamin on peripheral neuropathy: systematic review and meta-analysis. J Altern Complement Med. 2020;26:1117-1129. https://pubmed.ncbi.nlm.nih.gov/32716261/
Note: BioAbsorb is supplied strictly for investigational research use only. It is not approved or intended for diagnostic or therapeutic applications in humans or animals.
