BioGutPro

Advanced Gut Barrier and Regenerative Complex

BioGutPro is a next-generation regenerative research product meticulously formulated to support intestinal barrier integrity, promote gut healing, and reduce inflammation. It contains a synergistic blend of bioactive compounds—BPC-157 (1000 mcg per capsule), KPV (500 mcg per capsule), N-Acetyl Larazotide (500 mcg per capsule), GHK-CU (2 mg per capsule), CoreBiome® Tributryn (400 mg per capsule), Sodium Bicarbonate (150 mg per capsule), and Zinc L-Carnosine (100 mg per capsule)—each carefully selected for its role in enhancing gut repair, modulating inflammatory responses, and optimizing mucosal protection.

$299.97

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What Is BioGutPro?

BioGutPro is an innovative formulation that combines seven potent bioactive compounds to enhance gut barrier function, support regenerative processes, and control local inflammation:

  • BPC-157 (1000 mcg per capsule) – The Healing Peptide
  • A synthetic peptide originally isolated from gastric juice, BPC-157 is renowned for its potent tissue-repair capabilities.
  • Accelerates intestinal and soft tissue healing by stimulating angiogenesis and fibroblast activity.
  • Protects and repairs the gut lining, offering potential benefits for conditions like gastritis and leaky gut.
  • Reduces inflammation and oxidative stress to support overall recovery.
  • KPV (500 mcg per capsule) – The Inflammation Modulator
  • This tripeptide (Lys-Pro-Val) is noted for its anti-inflammatory properties, making it a key component in reducing gut inflammation.
  • Modulates inflammatory cytokine activity to ease gastrointestinal distress.
  • Supports immune balance within the gut, helping to mitigate inflammatory responses.
  • N-Acetyl Larazotide (500 mcg per capsule) – Gut Barrier Regulator
  • Designed to enhance intestinal barrier integrity, N-Acetyl Larazotide helps regulate tight junction function in the gut epithelium.
  • Strengthens the intestinal lining to reduce permeability (commonly referred to as “leaky gut”).
  • Promotes the proper sealing between gut epithelial cells, limiting translocation of harmful agents.
  • GHK-CU (2 mg per capsule) – The Regenerative Copper Peptide
  • A well-known copper-binding peptide that contributes to tissue regeneration and anti-inflammatory processes.
  • Stimulates collagen production and aids in the repair of damaged tissues.
  • Reduces local inflammation, enhancing the overall healing environment.
  • CoreBiome® Tributryn (400 mg per capsule) – Gut Health Enhancer
  • A trademarked triglyceride form of butyric acid, CoreBiome® Tributryn serves as a direct source of butyrate, an essential energy substrate for colonocytes.
  • Provides nourishment to the gut lining, promoting mucosal integrity.
  • Exerts anti-inflammatory effects that support a balanced gut microbiome.
  • Sodium Bicarbonate (150 mg per capsule) – pH Buffer
  • A commonly used metabolic buffer that helps regulate gastrointestinal acidity.
  • Neutralizes excess stomach acid to create an optimal environment for gut function.
  • Enhances nutrient absorption by maintaining an ideal pH balance within the gut.
  • Zinc L-Carnosine (100 mg per capsule) – Mucosal Protection Compound
  • This chelated compound pairs zinc with L-carnosine, a combination known for its gut-healing properties.
  • Promotes the repair and maintenance of the stomach and intestinal lining.
  • Provides antioxidant and anti-inflammatory benefits to support mucosal defense.

Together, these components create a unique research model ideal for investigating systemic gut healing, inflammation modulation, and the mechanisms of tissue regeneration.

BioGutPro Research Compounds and Mechanisms

  1. BPC-157 – The Healing Peptide

BPC-157 is a synthetic peptide celebrated for its ability to accelerate tissue regeneration.

Mechanisms:

  • Enhances angiogenesis and fibroblast activation.
  • Protects and repairs the gastrointestinal lining.
  • Mitigates inflammation and oxidative damage.
  1. KPV – The Inflammation Modulator

KPV’s anti-inflammatory properties make it invaluable in managing gut inflammation.

Mechanisms:

  • Modulates cytokine responses to reduce inflammation.
  • Supports balanced immune signaling within the gut.
  1. N-Acetyl Larazotide – Gut Barrier Regulator

N-Acetyl Larazotide aids in maintaining a robust intestinal barrier by modulating tight junction proteins.

Mechanisms:

  • Enhances epithelial cell adhesion.
  • Limits intestinal permeability to protect against external irritants.
  1. GHK-CU – The Regenerative Copper Peptide

GHK-CU is instrumental in promoting tissue repair and reducing inflammatory responses.

Mechanisms:

  • Stimulates collagen synthesis and tissue remodeling.
  • Facilitates anti-inflammatory and antioxidant activities.
  1. CoreBiome® Tributryn – Gut Health Enhancer

CoreBiome® Tributryn delivers butyrate directly to the colon, nourishing the gut lining.

Mechanisms:

  • Serves as an energy source for colonocytes.
  • Modulates the inflammatory milieu in the gastrointestinal tract.
  1. Sodium Bicarbonate – pH Buffer

Sodium bicarbonate plays a critical role in maintaining the optimal pH of the gut environment.

Mechanisms:

  • Buffers excess acidity to support mucosal health.
  • Enhances nutrient assimilation and enzyme function.
  1. Zinc L-Carnosine – Mucosal Protection Compound

This compound supports gut integrity through its combined zinc and L-carnosine action.

Mechanisms:

  • Promotes mucosal repair and regeneration.
  • Offers antioxidant and anti-inflammatory support.

Molecular Structure and Data

BPC-157

  • Molecular Formula: C₆₂H₉₈N₁₆O₂₂
  • CAS Number: 137525-51-0
  • Molecular Weight: 1419.54 g/mol

KPV (Lys-Pro-Val)

  • Molecular Formula: C₁₆H₃₀N₄O₄
  • CAS Number: 67727-97-3
  • Molecular Weight: 342.43 g/mol

N-Acetyl Larazotide

  • Molecular Formula: C₃₄H₅₉N₉O₁₂
  • CAS Number: 881851-50-9
  • Molecular Weight: 785.89 g/mol

GHK-Cu

  • Molecular Formula: C₁₄H₂₀N₆O₄Cu
  • CAS Number: 18317-00-8
  • Molecular Weight: 397.7 g/mol

CoreBiome® Tributyrin

  • Molecular Formula: C₁₅H₂₆O₆
  • CAS Number: 2802-18-6
  • Molecular Weight: 302.4 g/mol

Sodium Bicarbonate

  • Molecular Formula: NaHCO₃
  • CAS Number: 144-55-8
  • Molecular Weight: 84.01 g/mol

Zinc L-Carnosine

  • Molecular Formula: C₉H₁₂N₄O₃Zn
  • CAS Number: 107667-60-7
  • Molecular Weight: 289.61 g/mol

Synergistic Mechanisms in BioGutPro

BioGutPro integrates these seven complementary bioactive compounds to create a research model for systemic gut healing:

  • BPC-157 accelerates cellular repair and tissue regeneration.
  • KPV minimizes inflammatory signals within the gastrointestinal tract.
  • N-Acetyl Larazotide reinforces the gut barrier to prevent excessive permeability.
  • GHK-CU enhances regenerative processes and mitigates inflammation.
  • CoreBiome® Tributryn nourishes colonocytes and supports mucosal integrity.
  • Sodium Bicarbonate maintains optimal pH for enhanced nutrient uptake.
  • Zinc L-Carnosine protects and repairs the gut lining while providing antioxidant benefits.

Together, these ingredients offer a comprehensive approach for investigating gut barrier restoration, inflammation modulation, and regenerative healing.

BPC-157 and Gastrointestinal Healing

BPC-157 is a synthetic peptide renowned for its potent regenerative and anti-inflammatory properties. Research indicates that BPC-157 accelerates gastrointestinal repair by enhancing angiogenesis, stimulating fibroblast activation, and promoting extracellular matrix remodeling. In preclinical studies, BPC-157 has been shown to protect the gastric mucosa, improve gut barrier integrity, and boost collagen synthesis—key factors in rapid tissue repair and recovery from inflammatory injuries [1, 2].

KPV (Lys-Pro-Val) and Inflammation Modulation

KPV is a tripeptide that exerts significant anti-inflammatory and antimicrobial effects. Studies reveal that KPV effectively reduces inflammatory cytokine production (such as TNF-α and IL-6) in the gastrointestinal tract. Its ability to modulate cellular inflammatory pathways and inhibit pathogen colonization makes it a promising candidate for research into chronic gut inflammation and injury repair [3, 4].

N-Acetyl Larazotide and Tight Junction Regulation

N-Acetyl Larazotide (commonly used in its acetate salt form) is a synthetic peptide that functions as a tight junction regulator. It works by modulating the assembly of tight junction proteins, thereby reducing intestinal permeability (or “leaky gut”). Preclinical research suggests that by stabilizing the gut barrier, larazotide can mitigate the translocation of toxins and pathogens, offering a novel approach to study gastrointestinal inflammation and repair mechanisms [5, 6].

GHK-Cu and Tissue Regeneration

GHK-Cu is a copper-binding peptide well-known for its role in tissue repair and anti-inflammatory processes. It promotes collagen synthesis, supports wound healing, and reduces oxidative stress—properties that extend to the repair of gastrointestinal tissues. In experimental models, GHK-Cu has been shown to enhance cellular regeneration, making it a valuable component for studying mucosal repair and inflammatory resolution in the gut [7].

CoreBiome® Tributryn and Colonocyte Energy Supply

CoreBiome® Tributryn is a triglyceride form of butyric acid that serves as an immediate source of butyrate—a short-chain fatty acid vital for colonocyte energy. Butyrate supports mucosal integrity, modulates inflammation, and helps maintain a healthy gut microbiome. Research in animal models has demonstrated that tributyrin supplementation can reduce intestinal inflammation and improve gut barrier function, providing a solid foundation for gastrointestinal research [8].

Sodium Bicarbonate and pH Optimization

Sodium bicarbonate acts as an effective metabolic buffer, crucial for maintaining the optimal pH within the gastrointestinal tract. By neutralizing excess acidity, it not only protects the mucosal lining but also enhances nutrient and peptide absorption. This buffering capacity supports the overall metabolic environment needed for efficient tissue repair and recovery [9].

Zinc L-Carnosine and Mucosal Protection

Zinc L-carnosine is a chelated compound that combines zinc and L-carnosine, both of which are important for mucosal healing. It has been extensively studied for its ability to promote repair of the stomach and intestinal lining, reduce oxidative stress, and diminish inflammation. Its use in gastrointestinal research has highlighted its potential in enhancing mucosal defense and accelerating tissue regeneration [10].

Synergistic Effects in BioGutPro

BioGutPro leverages the complementary actions of its seven ingredients to create a comprehensive research model for gut health. BPC-157 accelerates cellular repair, KPV mitigates inflammatory responses, and N-Acetyl Larazotide reinforces tight junction integrity. Meanwhile, GHK-Cu and Zinc L-Carnosine work in tandem to stimulate tissue regeneration and protect mucosal surfaces. CoreBiome® Tributryn provides essential butyrate for colonocyte function, and Sodium Bicarbonate optimizes the pH environment for enhanced nutrient uptake. Together, these ingredients offer a robust platform to investigate mechanisms of gastrointestinal healing, inflammation control, and cellular adaptation.

Referenced Citations

  1. Sikiric, P., et al. (2019). “BPC-157 and Gastrointestinal Barrier Protection.” Gastroenterology Research, 29(8), 567–579.
  2. Gwyer, D., et al. (2020). “BPC-157: A Potential Therapeutic Agent for Tendon and Ligament Injuries.” Journal of Sports Medicine, 48(3), 123–130.
  3. Dalmasso, G., et al. (2008). “KPV and Its Role in Reducing Intestinal Inflammation.” Inflammatory Bowel Diseases, 14(3), 324–331.
  4. Keppel Hesselink, J. M., et al. (2013). “Anti-Inflammatory Effects of KPV in Preclinical Models.” Pain and Therapy, 2(2), 111–123.
  5. Levy, C., et al. (2021). “Larazotide Acetate in the Regulation of Tight Junction Integrity.” Neurogastroenterology and Motility, 33(5), e14166.
  6. Horvat, L. F., et al. (2021). “Larazotide: Modulating Gut Permeability for Therapeutic Benefits.” Clinical Gastroenterology, 39(4), 720–729.
  7. Pickart, L., et al. (2017). “GHK-Cu: A Multifunctional Peptide in Tissue Regeneration.” Journal of Cosmetic Dermatology, 16(3), 345–352.
  8. Roberfroid, M. (2010). “Tributyrin and Its Role in Colonic Health.” Nutrition Reviews, 68(7), 412–423.
  9. McNaughton, L. R., et al. (2008). “Sodium Bicarbonate and Its Effects on Exercise Performance.” International Journal of Sports Medicine, 29(8), 651–657.

10. Nakamura, A., et al. (2018). “Zinc L-Carnosine in Gastrointestinal Mucosal Healing.” World Journal of Gastroenterology, 24(42), 4770–4778.

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