What Is BioRestore?
BioRestore is a first-of-its-kind formulation that combines four powerful bioactive compounds to enhance recovery and support systemic healing:
- BPC-157 (1000mcg per capsule) – A synthetic peptide with potent healing properties, known for its ability to accelerate tissue repair, protect the gut lining, and reduce inflammation.
- Palmitoylethanolamide (PEA) (500mg per capsule) – A natural fatty acid amide that modulates pain and inflammation through the endocannabinoid system, offering potent neuroprotective and analgesic effects.
- Hyaluronic Acid (100mg per capsule) – A key structural component of connective tissue, supporting joint lubrication, cartilage regeneration, and skin hydration to optimize recovery.
- Sodium Bicarbonate (400mg per capsule) – A metabolic alkalizer that buffers acidity, enhances nutrient absorption, and optimizes cellular pH, creating an ideal environment for healing and repair.
Together, these compounds provide an unparalleled research opportunity to study tissue regeneration, pain modulation, and systemic inflammation control.
BioRestore Research Compounds and Mechanisms
- BPC-157 – The Healing Peptide
BPC-157 is a synthetic peptide derived from body protection compounds, naturally found in gastric juice. It has been extensively studied for its role in tissue repair and anti-inflammatory activity.
- Accelerates wound healing by promoting angiogenesis and fibroblast activation.
- Protects and repairs the gut lining, making it beneficial for conditions such as gastritis, leaky gut, and ulcerative colitis.
- Reduces inflammation and oxidative stress, supporting recovery from injuries and metabolic stress.
- Enhances musculoskeletal healing, making it ideal for joint, tendon, and ligament repair.
Studies suggest BPC-157 enhances the body’s innate repair mechanisms, making it a promising compound for research into chronic injuries and systemic inflammation.
- Palmitoylethanolamide (PEA) – Natural Inflammation Modulator
PEA is an endogenous fatty acid amide with potent neuroprotective and anti-inflammatory properties. It modulates the endocannabinoid system, acting as a powerful pain reliever and inflammation regulator.
- Activates PPAR-α receptors to control neuroinflammation and pain signaling.
- Reduces mast cell overactivation, which contributes to chronic pain and autoimmune responses.
- Supports nerve repair and neuroprotection, making it valuable in research on neuropathic pain and neurodegenerative conditions.
- Enhances endogenous cannabinoid function, allowing for improved pain tolerance and recovery.
PEA’s ability to reduce pain and inflammation without harmful side effects makes it a critical research compound for studying alternative pain management therapies.
- Hyaluronic Acid – The Joint & Tissue Hydration Molecule
Hyaluronic Acid is a naturally occurring glycosaminoglycan that plays a critical role in joint lubrication, skin hydration, and connective tissue resilience.
- Supports joint health and cartilage regeneration, reducing stiffness and pain.
- Enhances skin hydration and elasticity, improving extracellular matrix function.
- Promotes synovial fluid production, ensuring smooth joint movement and cushioning.
- Accelerates post-injury tissue repair, making it beneficial for recovery research.
Studies suggest that oral hyaluronic acid supplementation can increase systemic hydration and improve tissue resilience, making it an ideal co-factor for regenerative therapies.
- Sodium Bicarbonate – Cellular pH and Recovery Optimization
Sodium Bicarbonate is a metabolic buffer that helps regulate acidity, optimize nutrient absorption, and enhance recovery from metabolic stress.
- Buffers lactic acid, reducing exercise-induced fatigue and improving endurance.
- Optimizes cellular pH, ensuring optimal enzymatic function and repair processes.
- Enhances nutrient absorption, increasing the bioavailability of other active ingredients.
- Supports gut health, counteracting acidosis and reducing inflammation.
By creating a favorable pH environment for healing, sodium bicarbonate plays a critical role in enhancing the systemic effects of BioRestore.
BPC-157, PEA, Hyaluronic Acid, and Sodium Bicarbonate Synergy
BioRestore contains four complementary bioactive compounds that work synergistically to enhance recovery, reduce pain, and optimize cellular function:
- BPC-157 accelerates healing and tissue regeneration at the cellular level.
- PEA reduces inflammation and modulates pain, supporting long-term recovery.
- Hyaluronic Acid enhances hydration, joint function, and extracellular matrix stability.
- Sodium Bicarbonate optimizes cellular pH and nutrient absorption, improving systemic resilience.
Together, these compounds create an ideal research model for studying systemic healing, anti-inflammatory pathways, and regenerative medicine applications.
Molecular Structure and Data
BPC-157
- Molecular Formula: C₆₂H₉₈N₁₆O₂₂
- CAS Number: 137525-51-0
- Molecular Weight: 1419.54 g/mol
Palmitoylethanolamide (PEA)
- Molecular Formula: C₁₈H₃₇NO₂
- CAS Number: 544-31-0
- Molecular Weight: 299.49 g/mol
Hyaluronic Acid
- Molecular Formula: (C₁₄H₂₁NO₁₁)n
- CAS Number: 9004-61-9
- Molecular Weight: Variable
Sodium Bicarbonate
- Molecular Formula: NaHCO₃
- CAS Number: 144-55-8
- Molecular Weight: 84.01 g/mol
BPC-157 Arginine Salt and Tissue Regeneration
BPC-157 is a synthetic peptide with powerful healing and regenerative properties. It plays a crucial role in accelerating tissue repair, reducing inflammation, and protecting the gastrointestinal lining. Studies suggest that BPC-157 modulates angiogenesis (blood vessel formation), enhances fibroblast activation, and promotes extracellular matrix remodeling [1].
- Research indicates BPC-157 enhances collagen synthesis, leading to faster wound healing and musculoskeletal recovery [2].
- In preclinical models, BPC-157 has been shown to protect the gastric mucosa and support gut barrier integrity, making it a candidate for studying gastrointestinal repair mechanisms [3].
- BPC-157 reduces inflammatory cytokines, offering potential applications in chronic injury recovery and inflammatory conditions [4].
Palmitoylethanolamide (PEA) and Neuroinflammation Modulation
Palmitoylethanolamide (PEA) is an endogenous fatty acid amide that interacts with the endocannabinoid system to regulate pain, inflammation, and neuroprotection. It has been widely studied for its ability to modulate mast cell activity, reduce oxidative stress, and enhance neuroplasticity [5].
- Research shows PEA inhibits mast cell degranulation, effectively reducing neuroinflammation and chronic pain signaling [6].
- PEA activates PPAR-α receptors, which play a critical role in modulating immune responses and controlling metabolic inflammation [7].
- In experimental models, PEA has demonstrated analgesic properties, reducing neuropathic pain and inflammation without central nervous system side effects [8].
Hyaluronic Acid and Extracellular Matrix Integrity
Hyaluronic Acid is a glycosaminoglycan that serves as a key structural component in connective tissues, joints, and skin. It plays a critical role in maintaining hydration, reducing friction, and supporting tissue elasticity [9].
- Research demonstrates oral hyaluronic acid supplementation increases synovial fluid viscosity, improving joint lubrication and cartilage protection [10].
- Studies suggest hyaluronic acid enhances fibroblast activity, promoting collagen synthesis and wound healing [11].
- In animal models, hyaluronic acid has shown promise in reducing osteoarthritis progression and improving joint mobility [12].
Sodium Bicarbonate and pH Regulation
Sodium Bicarbonate is a metabolic buffer that plays a key role in regulating acid-base balance, optimizing enzyme function, and improving nutrient absorption. It is frequently used in sports performance research due to its ability to buffer lactic acid and delay muscular fatigue [13].
- Sodium bicarbonate increases blood pH, reducing metabolic acidosis and enhancing recovery from high-intensity physical stress [14].
- Studies show that sodium bicarbonate enhances nutrient bioavailability, particularly for amino acids and peptides involved in tissue regeneration [15].
- In experimental models, sodium bicarbonate has demonstrated anti-inflammatory effects, reducing oxidative stress markers associated with metabolic dysfunction [16].
- Synergistic Effects of BPC-157, PEA, Hyaluronic Acid, and Sodium Bicarbonate
BioRestore’s unique formulation combines BPC-157’s regenerative properties, PEA’s inflammation modulation, Hyaluronic Acid’s structural support, and Sodium Bicarbonate’s metabolic buffering, creating an optimized research model for healing, recovery, and cellular adaptation.
- BPC-157 accelerates tissue repair, while PEA reduces neuroinflammation, offering a dual-action approach to injury recovery [17].
- Hyaluronic Acid improves extracellular matrix integrity, while Sodium Bicarbonate optimizes cellular pH, enhancing joint function and metabolic resilience [18].
Referenced Citations
- Sikiric, P., et al. (2019). “BPC-157 and Gastrointestinal Barrier Protection.” Gastroenterology Research, 29(8), 567–579.
- Gwyer, D., et al. (2020). “BPC-157: A Potential Therapeutic Agent for Tendon and Ligament Injuries.” Journal of Sports Medicine, 48(3), 123–130.
- Levy, C., et al. (2021). “Neuroprotective Effects of BPC-157 in Central Nervous System Disorders.” Neuroscience Letters, 745, 135593.
- Horvat, L. F., et al. (2021). “BPC-157 as an Anti-Inflammatory Peptide.” Inflammation Research, 68, 523–531.
- Gabrielsson, L., et al. (2016). “Palmitoylethanolamide for the Treatment of Pain: A Meta-Analysis.” Pain Physician, 19(2), 11–24.
- Keppel Hesselink, J. M., et al. (2013). “Palmitoylethanolamide, a Natural Endocannabinoid-Like Compound, in the Treatment of Pain: Efficacy and Safety.” Pain and Therapy, 2(2), 111–123.
- Skaper, S. D., et al. (2014). “Palmitoylethanolamide: A Candidate for Neuroprotection in Glaucoma.” CNS & Neurological Disorders – Drug Targets, 13(6), 1002–1008.
- Petrosino, S., et al. (2017). “PEA and Mast Cell Modulation.” J. Neurochem., 142(9), 211–225.
- Altman, R. D., et al. (2015). “Intra-Articular Hyaluronic Acid Injections for Knee Osteoarthritis: A Meta-Analysis.” The Journal of Rheumatology, 42(9), 1800–1808.
- Wobig, M., et al. (1999). “The Role of Hyaluronic Acid in the Treatment of Osteoarthritis.” Clinical Therapeutics, 21(9), 1549–1562.
- Pagnano, M. W., et al. (2005). “Hyaluronic Acid in the Treatment of Knee Osteoarthritis: Evidence for Efficacy and Safety.” The Journal of Arthroplasty, 20(7), 74–79.
- Ragab, T., et al. (2019). “The Synergistic Effect of Hyaluronic Acid and Platelet-Rich Plasma in Osteoarthritis.” Journal of Orthopaedic Surgery and Research, 14(1), 202.
- Carr, A. J., et al. (2011). “Sodium Bicarbonate Supplementation Improves Performance in Elite Swimmers.” Medicine & Science in Sports & Exercise, 43(5), 829–835.
- McNaughton, L. R., et al. (2008). “Sodium Bicarbonate and High-Intensity Cycling Performance.” International Journal of Sports Medicine, 29(8), 651–657.
- Requena, B., et al. (2005). “Effect of Sodium Bicarbonate on Performance in Maximal Exercise.” European Journal of Applied Physiology, 94(1-2), 76–81.
- Esposito, E., et al. (2014). “Combined Therapy with Palmitoylethanolamide and Luteolin Reduces Neuroinflammation in Parkinson’s Disease.” Journal of Neuroinflammation, 11, 136.
- Lambert, C., et al. (2017). “The Effect of Sodium Bicarbonate on Muscular Strength and Endurance: A Systematic Review and Meta-Analysis.” Journal of Strength and Conditioning Research, 31(8), 233–245.
18. Smith, R. A., et al. (2018). “Mitochondria-Targeted Antioxidants as Therapies.” Pharmaceuticals, 11(4), 113.
No COAs available for this product.
