N-Acetyl Selank Amidate Product Description
Selank is a heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro)ย with significant anxiolytic, cognitive-enhancing, and immunomodulatory effects. Its ability to modulate the GABAergic system and influence gene expression underlies its therapeutic research potential, particularly in managing anxiety and stress-related conditions.
N-Acetyl Selank is a modified version of Selank designed to improve its pharmacological properties. The addition of an acetyl group at the N-terminus enhances its stability, potency, and ability to cross the blood-brain barrier.
Peptide Information
| Property |
Value |
| Peptide Sequence |
Ac-Thr-Lys-Pro-Arg-Pro-Gly-Pro-NH2 |
| Molecular Formula |
C33H57N11O9 |
| Molecular Weight |
751.9 g/mol |
| CAS Number |
129954-34-3 |
| PubChem CID |
11765600 |
| Synonyms |
Selank, 129954-34-3, Selanc, Thr-Lys-Pro-Arg-Pro-Gly-Pro, TP-7 |
N-Acetyl Selank Peptide Structure
Source PubChem
N-Acetyl Selank Research
Selank is a multifaceted peptide with significant potential in treating anxiety, cognitive impairments, and stress-related physiological changes. Its ability to modulate the GABAergic system, enhance cognitive function, and exert immunomodulatory effects positions it as a versatile therapeutic agent.
Anxiolytic and Cognitive Effects
Selank has demonstrated significant anxiolytic properties, comparable to classical benzodiazepines, without the associated side effects such as dependence and memoryย impairment1.ย It has been shown to reduce anxiety in conditions of chronic stress and improve cognitive functions, such as memory and attention, particularly in the context of ethanol-inducedย impairments.ย The peptide’s ability to regulate brain-derived neurotrophic factor (BDNF) content in the hippocampus and prefrontal cortex is thought to contribute to its cognitive-enhancingย effects2.
Immunomodulatory and Antiviral Properties
Beyond its neurological effects, Selank also exhibits immunomodulatory and antiviral properties. It can significantly alter the expression of genes related to chemokines, cytokines, and their receptors, suggesting a role in immune responseย modulation3.ย These properties make Selank a promising candidate for therapeutic applications beyond anxiety and cognitive disorders.
Stress Mitigation and Physiological Effects
Selank has been shown to mitigate stress-induced physiological changes. In animal models, it reduces stress-related morphological changes in organs such as the liver and colon, indicating its potential to alleviate stress-inducedย damage. These effects are likely due to its multifunctional biological activity, which includes reducing corticosterone levels and promoting adaptation toย stress4.
References
- Vyunova, T., Andreeva, L., Shevchenko, K., & Myasoedov, N. (2018). Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity..ย Protein and peptide letters, 25 10, 914-923 .ย https://doi.org/10.2174/0929866525666180925144642.
- Kolik, L., Nadorova, A., Antipova, T., Kruglov, S., Kudrin, V., & Durnev, A. (2019). Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.ย Bulletin of Experimental Biology and Medicine, 167, 641 – 644.ย https://doi.org/10.1007/s10517-019-04588-9.
- Kolomin, T., Mikhalskaia, P., & Sedelnikova, A. (2023). Changes in Expression of Chemokines, Cytokines and their Receptors under the Action of Selank and its Fragments.ย Journal of Clinical Physiology and Pathology.ย https://doi.org/10.59315/jiscpp.2023-2-2.16-18.
- Mukhina, A., Mishina, E., Bobyntsev, I., Medvedeva, O., Svishcheva, M., Kalutskiฤญ, P., Andreeva, L., & Myasoedov, N. (2020). Morphological Changes in the Large Intestine of Rats Subjected to Chronic Restraint Stress and Treated with Selank.ย Bulletin of Experimental Biology and Medicine, 169, 281 – 285.ย https://doi.org/10.1007/s10517-020-04868-9.
