Opens in a new tab
Home
>
Shop
>
Epithalon (20mg)

Epithalon (20mg)

$94.97

Epithalon, also known as Epitalon, is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly (AEDG). It is produced through controlled solid-phase peptide synthesis and supplied as a lyophilized powder for stability during storage and handling. The compound is characterized in laboratory research examining telomere biology, gene-expression regulation, and pineal-linked signaling pathways. Every compound is third-party tested and its Certificate of Analysis is published online, so the testing record can be reviewed before purchase. Supplied for research use only.

≥99% Purity

Third-Party Tested

COA Available

U.S. Manufactured

Quantity

In stock

Third-Party Verified Quality

≥99% purity verified through independent UHPLC-MS testing. Certificates of Analysis are available before purchase.

  • COAs available before purchase
  • U.S.-manufactured research-grade
  • Same-business-day U.S. dispatch for in-stock orders placed before 12 PM PT
  • Secure Checkout · Free shipping on orders over $400
Epithalon (261474)
Latest Certificate of AnalysisEpithalon (261474)View all COAs →

Epithalon Technical Overview

Epithalon is a short synthetic peptide built from four amino acids in the sequence Ala-Glu-Asp-Gly. Its structure was modeled on the amino acid composition of Epithalamin, a pineal gland extract studied in gerontology research.

As a defined tetrapeptide, Epithalon is well suited to analytical and mechanistic work. It is supplied as a filler-free lyophilized powder and reconstituted with a sterile solvent immediately before experimental use.

The compound sits within the pineal and AEDG peptide research area, alongside related bioregulator compounds studied for cellular signaling and regulatory function.

Compound Specifications

Property Value
CAS Number 307297-39-8
PubChem CID 219042
Molecular Formula C₁₄H₂₂N₄O₉
Molecular Weight 390.35 g/mol
Amino Acid Sequence Ala-Glu-Asp-Gly (AEDG)
Sequence Length 4 residues (tetrapeptide)
IUPAC L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-glycine
Synonyms Epitalon, Epithalone, AEDG peptide
Source Synthetic
Purity ≥99% (HPLC)
Appearance Lyophilized white powder
Solubility Soluble in water
Storage -20°C, protect from light

Epithalon Peptide Structure

Epithalon peptide structure

Source: PubChem

Research Applications

Research Area In Vitro Application
Telomere biology Experimental systems measuring telomerase-associated activity and telomere-length metrics in cell-based models
Gene expression Assays quantifying transcriptional changes in defined differentiation markers
Epigenetic regulation Molecular-modeling and binding studies of peptide and histone interactions
Peptide characterization Analytical evaluation of tetrapeptide identity, sequence, and stability

Storage and Handling

  • Store the lyophilized compound at -20°C, protected from light.
  • After reconstitution, store at 2-8°C and use promptly.
  • Maintain aseptic handling to preserve compound integrity.

Frequently Asked Questions

What Is Epithalon Peptide?

Epithalon, also spelled Epitalon, is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly (AEDG). BioLongevity Labs supplies it as a filler-free lyophilized powder at ≥99% purity (HPLC) for research use only.

Is Epithalon the Same as Epithalamin?

No. Epithalamin is a pineal gland extract, while Epithalon is a defined four-residue synthetic peptide whose sequence was modeled on the amino acid composition of that extract.

What Are the Molecular Weight and CAS Number of Epithalon?

Epithalon has a molecular weight of 390.35 g/mol and the molecular formula C₁₄H₂₂N₄O₉. Its CAS Number is 307297-39-8 and its PubChem CID is 219042.

What Research Area Is Epithalon Studied In?

Epithalon is characterized in laboratory research on telomere biology, including telomerase-associated activity and telomere-length metrics in cell-based models. It is also studied in gene-expression and epigenetic regulation research.

How Should Epithalon Be Stored?

Store lyophilized Epithalon at -20°C, protected from light.

Research Overview

In telomere-biology research models, Epithalon has been associated with changes in telomerase-associated activity and telomere-length metrics. Cell-line studies have reported telomere-length extension linked to hTERT expression and telomerase upregulation [2]. Comparable telomere-length changes have been observed in lymphocyte models across adult study populations [4].

Epithalon has also been examined for transcriptional effects. In stem-cell models, the AEDG peptide was associated with changes in the expression of neuronal differentiation markers, and molecular-modeling work proposed a histone-interaction mechanism as one possible basis [3].

Within the broader short-peptide literature, AEDG has been studied as a regulator of cell differentiation [5]. A 2025 review consolidates the analytical, in vitro, and in silico characterization of the tetrapeptide reported to date [1].

Reported endpoints across this work are measured under defined laboratory conditions, which is the context the tetrapeptide has been characterized in to date.

Telomere-Associated Research

Telomere-focused work with Epithalon centers on enzymology and length measurement in cell-based systems. Reported endpoints include telomerase-associated activity, telomere-length metrics, and downstream genome-integrity markers, measured under defined laboratory conditions [2].

References

  1. Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. (2025). Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms26062691
  2. Al-Dulaimi S, Thomas R, Matta S, Roberts T. (2025). Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. https://doi.org/10.1007/s10522-025-10315-x (see also the published correction, https://doi.org/10.1007/s10522-025-10326-8)
  3. Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. (2020). AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. https://doi.org/10.3390/molecules25030609
  4. Khavinson VK, Pendina AA, Efimova OA, et al. (2019). Effect of Peptide AEDG on Telomere Length and Mitotic Index of PHA-Stimulated Human Blood Lymphocytes. Bulletin of Experimental Biology and Medicine. https://doi.org/10.1007/s10517-019-04664-0
  5. Khavinson V, Linkova N, Diatlova A, Trofimova S. (2020). Peptide Regulation of Cell Differentiation. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-019-09938-8

Certificate of Analysis (COA)

Epithalon (261474)

Epithalon (261474)

Epithalon (260821)

Epithalon (260821)

Epithalon (12097)

Epithalon (12097)

Epithalon (260259)

Epithalon (260259)

Ephitalon(10920)

Ephitalon(10920)

Epithalon (2502050023)

Epithalon (2502050023)



A Certificate of Analysis (COA) is a document that verifies a compound’s identity, purity and quality through independent laboratory testing. Every compound from BioLongevity Labs is third-party tested, and its COA is published here, so researchers can review the testing record before a compound enters a protocol.

Each COA reports results from third-party laboratory analysis, including:

  • Ultra-high-performance liquid chromatography with mass spectrometry (UHPLC-MS) for purity, measured against a 98% or 99% specification depending on the compound
  • Mass identification for molecular confirmation and content quantitation
  • Endotoxin testing by Limulus amebocyte lysate (LAL) or recombinant Factor C (rFC) assay, depending on the laboratory
  • Visual and physical characterization of the finished material

How to Verify a COA Independently

You can check every certificate against the issuing laboratory’s own records, not just the copy hosted here. Verification does not depend on BioLongevity Labs.

  • AV Analytics certificates carry a search code. Scan the QR code on the certificate to open the laboratory’s verification page, or enter the search code at avanalytical.com/coa-search to pull the official record.
  • BioRegen reports of analysis carry a Report ID and a Validation Key. Scan the QR code on the certificate to open the official record, or quote both identifiers when you contact the laboratory at the address printed on the report.
  • SafeCert Labs issued a number of earlier certificates. Each one carries a COA number and the signature of the reporting chemist. Quote that number when you ask the laboratory to confirm it.
  • Older certificates from other laboratories list their own verification details on the document.

When a batch is sent to more than one laboratory, each certificate resolves at its own issuing laboratory. A researcher can then check the results against two unrelated sources.

These COAs come from independent certified laboratories, not in-house testing. That gives researchers a verifiable record of molecular integrity for each compound. All compounds are supplied for research use only.

Review the latest COAs for this product below, or browse the full COA library.

Related products

99%+ Purity Verified

99%+ Purity Verified

Measured by UHPLC-MS and shown on every COA.

Independent Lab Tested

Third-Party Tested

Verified by AV Analytics, BioRegen and SafeCert.

Open COA Library

Open COA Library

Read any certificate before ordering. No account needed.

Same Day Shipping

Same Day Shipping

Orders placed before 12 PM PT ship the same business day.

USA Manufactured

USA Manufactured

Synthesis, testing and fulfillment all stay domestic.

Scientific Reviewer

Scientifically reviewed by Dr. Ky H. Le, MD. Dr. Le is a board-certified family medicine physician with over 20 years of clinical experience. Dr. Le validates the scientific accuracy of all technical content and research citations.

Disclaimer: For Research Purposes Only

This content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions about specific peptides and their researched benefits, is presented for informational purposes only and must not be construed as health, clinical, or legal guidance, nor an encouragement for non-research use. Peptides described here are solely for use in structured scientific study by authorized individuals. We advise consulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining or utilizing these peptides. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research peptides.
Epithalon - Research Peptide, BioLongevity Labs

Epithalon (20mg)

Please select a variation

$94.97

Are you over 21 years of age?