Pancragen Product Description
Pancragen is a four-residue peptide built from lysine, glutamic acid, aspartic acid, and tryptophan. Its low molecular weight and charge distribution place it in the class of short regulatory peptides that have been examined for nuclear localization and direct interaction with chromatin.
The compound is one of several tissue-designated short peptides developed at the Saint Petersburg Institute of Bioregulation and Gerontology. Within that series, KEDW is the sequence associated with pancreatic tissue research models, while related sequences such as AEDL and AEDG are associated with other tissue types.
Laboratory interest in Pancragen centers on two research threads. The first is its interaction with DNA and histone proteins at defined nucleotide motifs. The second is the pattern of differentiation-marker expression observed in cultured pancreatic cells exposed to the peptide.
Compound Specifications
| Property | Value |
|---|---|
| PubChem CID | 68452877 |
| Molecular Formula | C₂₆H₃₆N₆O₉ |
| Molecular Weight | 576.60 g/mol |
| Monoisotopic Mass | 576.25438 Da |
| Amino Acid Sequence | H-Lys-Glu-Asp-Trp-OH (KEDW) |
| Sequence Length | 4 residues |
| IUPAC Name | (4S)-5-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-1-oxopropan-2-yl]amino]-4-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoic acid |
| InChIKey | PIGJHNNSOMRLST-LEAZDLGRSA-N |
| Canonical SMILES | C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCN)N |
| Source | Synthetic |
| Related Amide Form | H-Lys-Glu-Asp-Trp-NH₂ (PubChem CID 68451868, C₂₆H₃₇N₇O₈, 575.6 g/mol) |
| Purity | ≥99% (HPLC) |
| Appearance | Lyophilized white powder |
| Solubility | Soluble in water; sterile bacteriostatic water is commonly used for reconstitution |
| Storage | -20°C, protect from light |
Storage and Handling
- Store the lyophilized compound at -20°C, protected from light and moisture.
- After reconstitution, store at 2°C to 8°C and use promptly; for extended holding, aliquot and store at -20°C to limit freeze-thaw cycles.
- Allow the sealed vial to equilibrate to room temperature before opening to reduce condensation on the powder.
- Maintain aseptic handling throughout to preserve compound integrity.
Lyophilized Format
This compound ships in lyophilized (freeze-dried) form. Freeze-drying supports long-term storage stability and preserves compound integrity. No fillers are added.
