DSIP peptide, also known as Delta Sleep-Inducing Peptide or emideltide, is a synthetic nonapeptide used in laboratory research. It is supplied as a lyophilized powder in a 5mg vial. Research applications include neuropeptide signaling, peptide conformation, and interactions with lipid membranes.
≥99% Purity
Third-Party Tested
COA Available
U.S. Manufactured
Quantity
In stock
Third-Party Verified Quality
≥99% purity verified through independent UHPLC-MS testing. Certificates of Analysis are available before purchase.
COAs available before purchase
U.S.-manufactured research-grade
Same-business-day U.S. dispatch for in-stock orders placed before 12 PM PT
Secure Checkout · Free shipping on orders over $400
DSIP consists of nine amino acid residues in the sequence WAGGDASGE. Its tryptophan residue provides a useful feature for spectroscopic studies of peptide structure and molecular interactions.
Laboratory research examines DSIP’s structure in solution, interactions with lipid membranes, and effects on neuronal signaling in experimental models. Its molecular conformation can change with the surrounding environment, making solvent and assay conditions relevant to experimental design.
Compound Specifications
Property
Value
Compound Class
Synthetic nonapeptide
Research Area
Neuropeptide signaling, peptide conformation, and membrane interactions
-20°C in the sealed vial, protected from light and moisture
Storage and Handling
Store the lyophilized compound at -20°C in the sealed vial, protected from light and moisture.
After reconstitution, store at 2°C to 8°C and use promptly; for longer holds, aliquot and store at -20°C to avoid repeated freeze-thaw cycles.
Allow the vial to reach ambient temperature before opening so condensation does not enter the powder.
Maintain aseptic handling to preserve compound integrity.
Lyophilized Format
This compound ships in lyophilized (freeze-dried) form. Freeze-drying supports long-term storage stability and preserves compound integrity. No fillers are added.
Research Use Disclaimer
DSIP is supplied for research use only. This material is not supplied as a drug, food, cosmetic, or dietary supplement. By purchasing, the buyer confirms the material will be used solely for in vitro research.
Research Overview
Spectroscopic studies of DSIP used nuclear magnetic resonance, circular dichroism, infrared spectroscopy, and fluorescence to examine its structure in solution. The findings described an equilibrium between folded and unordered conformations.[1] Further work examined how lipid membranes influence peptide conformation.[2]
In rat neuronal preparations, DSIP altered GABA-activated currents and NMDA-associated responses. Synaptosome experiments also measured changes in calcium uptake.[3] These findings concern experimental signaling responses and do not establish a selective DSIP-specific receptor.
Materials research has examined DSIP adsorption and release from charged polymer matrices. Retention and release differed with matrix charge and the surrounding solution.[4] These observations support laboratory studies of peptide–material interactions; they do not establish performance for every formulation.
Possible in vitro research applications include the following.
Research Area
In Vitro Application
Peptide Conformation
Examine DSIP structure using spectroscopic methods under defined solution conditions
Membrane Interactions
Compare peptide behavior in aqueous and lipid environments
Neuronal Signaling
Measure electrophysiological responses in a suitable neuronal preparation with appropriate controls
Peptide–Material Interactions
Investigate adsorption and release in defined polymer-matrix systems
References
Gray RA, Vander Velde DG, Burke CJ, et al. (1994). Delta-sleep-inducing peptide: solution conformational studies of a membrane-permeable peptide. Biochemistry, 33(6), 1323-31. DOI. PubMed. PMID 8312250.
Polverini E, Casadio R, Neyroz P, et al. (1998). Conformational changes of neuromedin B and delta sleep-inducing peptide induced by their interaction with lipid membranes as revealed by spectroscopic techniques and molecular dynamics simulation. Archives of biochemistry and biophysics, 349(2), 225-35. DOI. PubMed. PMID 9448709.
Grigor’ev VV, Ivanova TA, Kustova EA, et al. (2006). Effects of delta sleep-inducing peptide on pre- and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats. Bulletin of experimental biology and medicine, 142(2), 186-8. DOI. PubMed. PMID 17369935.
Sukhanova TV, Artyukhov AA, Gurevich YM, et al. (2014). Delta-sleep inducing peptide entrapment in the charged macroporous matrices. Materials science & engineering. C, Materials for biological applications, 42, 461-5. DOI. PubMed. PMID 25063142.
A Certificate of Analysis (COA) is a document that verifies a compound’s identity, purity and quality through independent laboratory testing. Every compound from BioLongevity Labs is third-party tested, and its COA is published here, so researchers can review the testing record before a compound enters a protocol.
Each COA reports results from third-party laboratory analysis, including:
Ultra-high-performance liquid chromatography with mass spectrometry (UHPLC-MS) for purity, measured against a 98% or 99% specification depending on the compound
Mass identification for molecular confirmation and content quantitation
Endotoxin testing by Limulus amebocyte lysate (LAL) or recombinant Factor C (rFC) assay, depending on the laboratory
Visual and physical characterization of the finished material
How to Verify a COA Independently
You can check every certificate against the issuing laboratory’s own records, not just the copy hosted here. Verification does not depend on BioLongevity Labs.
AV Analytics certificates carry a search code. Scan the QR code on the certificate to open the laboratory’s verification page, or enter the search code at avanalytical.com/coa-search to pull the official record.
BioRegen reports of analysis carry a Report ID and a Validation Key. Scan the QR code on the certificate to open the official record, or quote both identifiers when you contact the laboratory at the address printed on the report.
SafeCert Labs issued a number of earlier certificates. Each one carries a COA number and the signature of the reporting chemist. Quote that number when you ask the laboratory to confirm it.
Older certificates from other laboratories list their own verification details on the document.
When a batch is sent to more than one laboratory, each certificate resolves at its own issuing laboratory. A researcher can then check the results against two unrelated sources.
These COAs come from independent certified laboratories, not in-house testing. That gives researchers a verifiable record of molecular integrity for each compound. All compounds are supplied for research use only.
Scientifically reviewed by Dr. Ky H. Le, MD. Dr. Le is a board-certified family medicine physician with over 20 years of clinical experience. Dr. Le validates the scientific accuracy of all technical content and research citations.
Disclaimer: For Research Purposes Only
This content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions about specific peptides and their researched benefits, is presented for informational purposes only and must not be construed as health, clinical, or legal guidance, nor an encouragement for non-research use. Peptides described here are solely for use in structured scientific study by authorized individuals. We advise consulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining or utilizing these peptides. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research peptides.
