Pinealon peptide is a synthetic tripeptide of the defined sequence Glu-Asp-Arg, also known as the EDR peptide, produced through controlled chemical peptide synthesis. BioLongevity Labs supplies Pinealon 20mg as a lyophilized white powder in a sealed vial, with purity of ≥99% confirmed by HPLC. The compound belongs to the short-peptide bioregulator family. It is characterized in laboratory research on peptide and DNA interactions, oxidative stress signaling, and neuronal cell culture models.
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Pinealon is a three-residue peptide built from L-glutamic acid, L-aspartic acid, and L-arginine. It is one of the short regulatory peptides described by V. Kh. Khavinson and colleagues at the Saint Petersburg Institute of Bioregulation and Gerontology.
Unlike larger signaling peptides studied for receptor binding at the cell surface, the EDR peptide is examined for its ability to enter the cell nucleus and bind specific DNA sequences. That property places it in epigenetic and gene-expression research.
Each 20mg vial is supplied in freeze-dried form for stable storage. Researchers use it in cell culture, molecular docking, and oxidative stress assay work under controlled laboratory conditions.
Store the lyophilized compound at -20°C, protected from light and moisture.
After reconstitution, store at 2–8°C and use promptly.
Maintain aseptic handling to preserve compound integrity.
Lyophilized Format
This compound ships in lyophilized (freeze-dried) form. Freeze-drying supports long-term storage stability and preserves compound integrity. No fillers are added.
Research Use Disclaimer
Pinealon is supplied for research use only. It is not a drug, food, cosmetic, or dietary supplement and has not been evaluated by the FDA. By purchasing, the buyer confirms the compound will be used solely for in vitro research.
Frequently Asked Questions
What Is Pinealon Peptide?
Pinealon peptide is a synthetic tripeptide with the sequence Glu-Asp-Arg, which is why it is also called the EDR peptide. It belongs to the short-peptide bioregulator family and is studied in gene-expression and cell culture research.
What Is the Molecular Weight of Pinealon?
Pinealon has a molecular weight of 418.40 g/mol and the molecular formula C₁₅H₂₆N₆O₈. Its CAS number is 175175-23-2 and its PubChem CID is 10273502.
Where Can I Buy Pinealon Peptide for Research?
BioLongevity Labs supplies Pinealon 20mg for research use only as a lyophilized powder with ≥99% HPLC purity. A third-party Certificate of Analysis is published for each batch before purchase.
How Should Pinealon 20mg Be Stored?
Lyophilized Pinealon should be kept at -20°C, protected from light and moisture. Once reconstituted, the solution should be held at 2–8°C and used promptly.
What Research Areas Is Pinealon Studied In?
Pinealon is studied in laboratory models of peptide and DNA binding, reactive oxygen species signaling, and neuronal cell culture. Recent work has examined dendritic morphology in cultured and induced neurons.
Research Overview
Pinealon is one of several short peptides examined for direct interaction with nuclear material. In HeLa cell experiments, fluorescein-labeled Pinealon appeared in the cytoplasm, nucleus, and nucleolus, and fluorescence quenching assays indicated preferential binding to CAG-containing deoxyribooligonucleotides [1].
In rat cerebellar granule cells, neutrophils, and PC12 cells, Pinealon restricted reactive oxygen species accumulation in a concentration-dependent manner and lowered necrotic cell death in the propidium iodide test [2]. These changes were accompanied by delayed ERK 1/2 activation and modification of the cell cycle [2].
A 2020 review proposes that the EDR peptide enters cells and binds histone proteins or nucleic acids. Through that route it may alter MAPK/ERK signaling and the synthesis of caspase-3, p53, SOD2, GPX1, PPARA, and PPARG [3].
Two research threads have drawn most of the follow-up work on Pinealon.
Gene Expression and Serotonin Synthesis Models
In aging cultures of rat brain cortex cells, Glu-Asp-Arg was associated with increased serotonin expression [4]. Molecular docking identified a CCTGCC sequence in the tryptophan hydroxylase gene that is complementary to the peptide [4].
Dendritic Spine and Neuronal Aging Models
In 5xFAD transgenic mice, the EDR peptide prevented dendritic spine loss, and docking studies located predicted binding sites in the promoter regions of several genes examined in that model [5].
In cortical neurons induced from aged donor dermal fibroblasts, EDR increased dendritic arborization and lowered oxidative DNA damage, with no change in mitochondrial or lysosomal activity [6]. In a rat model of elevated prenatal homocysteine, cerebellar neurons isolated from offspring showed lower reactive oxygen species accumulation and fewer necrotic cells [7].
Research Area
In Vitro Application
Peptide and DNA Interaction
Nuclear uptake imaging and binding assays with deoxyribooligonucleotides
Oxidative Stress Signaling
Reactive oxygen species accumulation and ERK 1/2 activation in cerebellar granule cell and PC12 cultures
Cell Viability
Necrotic cell death by propidium iodide staining and cell cycle analysis
Neuronal Morphology
Dendritic arborization and spine density in cultured and induced neurons
Neurotransmitter Synthesis
Serotonin and tryptophan hydroxylase expression in cortical cell cultures
Molecular Modeling
Docking of tripeptides against promoter DNA sequences
References
Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF (2011). Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Moscow). https://doi.org/10.1134/S0006297911110022
Khavinson V, Ribakova Y, Kulebiakin K, et al. (2011). Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Research. https://doi.org/10.1089/rej.2011.1172
Khavinson V, Linkova N, Kozhevnikova E, Trofimova S (2020). EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease. Molecules. https://pmc.ncbi.nlm.nih.gov/articles/PMC7795577/
Khavinson VKh, Lin’kova NS, Tarnovskaya SI, et al. (2014). Short peptides stimulate serotonin expression in cells of brain cortex. Bulletin of Experimental Biology and Medicine. https://doi.org/10.1007/s10517-014-2496-y
Khavinson V, Ilina A, Kraskovskaya N, et al. (2021). Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer’s Disease. Pharmaceuticals. https://pmc.ncbi.nlm.nih.gov/articles/PMC8227791/
Kraskovskaya N, Linkova N, Sakhenberg E, et al. (2024). Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes. International Journal of Molecular Sciences. https://pmc.ncbi.nlm.nih.gov/articles/PMC11546785/
Arutjunyan A, Kozina L, Stvolinskiy S, et al. (2012). Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. International Journal of Clinical and Experimental Medicine. https://pmc.ncbi.nlm.nih.gov/articles/PMC3342713/
A Certificate of Analysis (COA) is a document that verifies a compound’s identity, purity and quality through independent laboratory testing. Every compound from BioLongevity Labs is third-party tested, and its COA is published here, so researchers can review the testing record before a compound enters a protocol.
Each COA reports results from third-party laboratory analysis, including:
Ultra-high-performance liquid chromatography with mass spectrometry (UHPLC-MS) for purity, measured against a 98% or 99% specification depending on the compound
Mass identification for molecular confirmation and content quantitation
Endotoxin testing by Limulus amebocyte lysate (LAL) or recombinant Factor C (rFC) assay, depending on the laboratory
Visual and physical characterization of the finished material
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Scientifically reviewed by Dr. Ky H. Le, MD. Dr. Le is a board-certified family medicine physician with over 20 years of clinical experience. Dr. Le validates the scientific accuracy of all technical content and research citations.
Disclaimer: For Research Purposes Only
This content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions about specific peptides and their researched benefits, is presented for informational purposes only and must not be construed as health, clinical, or legal guidance, nor an encouragement for non-research use. Peptides described here are solely for use in structured scientific study by authorized individuals. We advise consulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining or utilizing these peptides. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research peptides.
