BioG1 Technical Overview
BioG1 belongs to the family of acylated GLP-1 analogs. Its backbone follows the GLP-1(7-37) sequence, with two amino acid substitutions: 2-aminoisobutyric acid (Aib) in place of alanine at position 8 and arginine in place of lysine at position 34.
The single remaining lysine, at position 26, carries a side chain built from one gamma-glutamic acid unit, two 8-amino-3,6-dioxaoctanoic acid (OEG) spacers and an 18-carbon diacid. This lipidated side chain is the structural feature linked to reversible serum albumin binding in research models.
The compound appears in the literature under the research designations NN9535 and NNC 0113-0217. Laboratory work with this BioG1 research peptide centers on GLP-1 receptor pharmacology, albumin binding, receptor structure and pancreatic beta-cell line models.
Compound Specifications
| Property | Value |
|---|---|
| CAS Number | 910463-68-2 |
| PubChem CID | 56843331 |
| Molecular Formula | C₁₈₇H₂₉₁N₄₅O₅₉ |
| Molecular Weight | 4113.6 g/mol |
| Monoisotopic Mass | 4111.1154 Da |
| InChIKey | DLSWIYLPEUIQAV-CCUURXOWSA-N |
| UNII | 53AXN4NNHX |
| Synonyms | NN9535, NN-9535, NNC 0113-0217 |
| Amino Acid Sequence (Three-Letter) | H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(side chain)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH |
| Amino Acid Sequence (One-Letter) | H-(Aib)-EGTFTSDVSSYLEGQAAK(side chain)EFIAWLVRGRG-OH |
| Sequence Length | 31 residues |
| Lys26 Side Chain | N6-[gamma-Glu-2xOEG-17-carboxyheptadecanoyl] (C18 diacid) |
| Source | Synthetic |
| Strength | 10mg per vial |
| Purity | ≥99% (HPLC) |
| Appearance | Lyophilized white powder |
| Solubility | Soluble in water (to 1 mg/mL) |
| Storage | -20°C, protect from light and moisture |
Storage and Handling
- Store the lyophilized compound at -20°C, sealed and protected from light and moisture.
- After reconstitution, store at 2-8°C and use promptly. Avoid repeated freeze-thaw cycles.
- Maintain aseptic handling to preserve compound integrity.
Lyophilized Format
This compound ships in lyophilized (freeze-dried) form. Freeze-drying supports long-term storage stability and preserves compound integrity. No fillers are added.
Research Use Disclaimer
BioG1 is supplied for research use only. It is not a drug, food, cosmetic, or dietary supplement and has not been evaluated by the FDA. By purchasing, the buyer confirms the compound will be used solely for in vitro research.
