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Glass vial with standard cap labeled Epithalon 20MG 99% Purity from Biolongevity Labs.
Epithalon (20mg) - Image 2

Epithalon (20mg)

Epithalon, also known as Epitalon, is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly (AEDG). It is produced through controlled solid-phase peptide synthesis and supplied as a lyophilized powder for stability during storage and handling. The compound is characterized in laboratory research examining telomere biology, gene-expression regulation, and pineal-linked signaling pathways. Each batch is third-party tested and ships with a Certificate of Analysis for research use only.

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Description
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Description
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Epithalon Product Description

Epithalon is a short synthetic peptide built from four amino acids in the sequence Ala-Glu-Asp-Gly. Its structure was modeled on the amino acid composition of Epithalamin, a pineal gland extract studied in gerontology research.

As a defined tetrapeptide, Epithalon is well suited to analytical and mechanistic work. It is supplied as a filler-free lyophilized powder and reconstituted with a sterile solvent immediately before experimental use.

The compound sits within the pineal and AEDG peptide research area, alongside related bioregulator compounds studied for cellular signaling and regulatory function.

Compound Specifications

Property Value
CAS Number 307297-39-8
PubChem CID 219042
Molecular Formula C₁₄H₂₂N₄O₉
Molecular Weight 390.35 g/mol
Amino Acid Sequence Ala-Glu-Asp-Gly (AEDG)
Sequence Length 4 residues (tetrapeptide)
IUPAC L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-glycine
Synonyms Epitalon, Epithalamin, AEDG peptide
Source Synthetic
Purity ≥99% (HPLC)
Appearance Lyophilized white powder
Solubility Soluble in water
Storage -20°C, protect from light

Epithalon Peptide Structure

Epithalon peptide structure

Source: PubChem

Research Applications

Research Area In Vitro Application
Telomere biology Experimental systems measuring telomerase-associated activity and telomere-length metrics in cell-based models
Gene expression Assays quantifying transcriptional changes in defined differentiation markers
Epigenetic regulation Molecular-modeling and binding studies of peptide and histone interactions
Peptide characterization Analytical evaluation of tetrapeptide identity, sequence, and stability

Storage and Handling

  • Store the lyophilized compound at -20°C, protected from light.
  • After reconstitution, store at 2-8°C and use promptly.
  • Maintain aseptic handling to preserve compound integrity.

What Research Shows

In telomere-biology research models, Epithalon has been associated with changes in telomerase-associated activity and telomere-length metrics. Cell-line studies have reported telomere-length extension linked to hTERT expression and telomerase upregulation [2]. Comparable telomere-length changes have been observed in lymphocyte models across adult study populations [4].

Epithalon has also been examined for transcriptional effects. In stem-cell models, the AEDG peptide was associated with changes in the expression of neuronal differentiation markers, and molecular-modeling work proposed a histone-interaction mechanism as one possible basis [3].

Within the broader short-peptide literature, AEDG has been studied as a regulator of cell differentiation [5]. A 2025 review consolidates the analytical, in vitro, and in silico characterization of the tetrapeptide reported to date [1].

Researchers studying pineal-linked signaling often examine Epithalon alongside related compounds.

Telomere-Associated Research

Telomere-focused work with Epithalon centers on enzymology and length measurement in cell-based systems. Reported endpoints include telomerase-associated activity, telomere-length metrics, and downstream genome-integrity markers, measured under defined laboratory conditions [2].

References

  1. Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. (2025). Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms26062691
  2. Al-Dulaimi S, Thomas R, Matta S, Roberts T. (2025). Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. https://doi.org/10.1007/s10522-025-10315-x
  3. Khavinson V, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B. (2020). AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism. Molecules. https://doi.org/10.3390/molecules25030609
  4. Khavinson VK, Pendina AA, Efimova OA, et al. (2019). Effect of Peptide AEDG on Telomere Length and Mitotic Index of PHA-Stimulated Human Blood Lymphocytes. Bulletin of Experimental Biology and Medicine. https://doi.org/10.1007/s10517-019-04664-0
  5. Khavinson V, Linkova N, Diatlova A, Trofimova S. (2020). Peptide Regulation of Cell Differentiation. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-019-09938-8

Certificate of Analysis (COA) for Every Batch

A Certificate of Analysis (COA) is a document that verifies a compound’s identity, purity, and batch quality through independent laboratory testing. Every compound from BioLongevity Labs ships with a COA tied to its specific batch, so researchers can confirm exactly what they received before it enters a protocol.

Each COA reports results from third-party laboratory analysis, including:

  • High-performance liquid chromatography (HPLC) for purity, typically confirmed at 99% or higher
  • Liquid chromatography mass spectrometry (LC-MS) for molecular identity and mass confirmation
  • Sterility and endotoxin screening where applicable
  • Chemical contaminant and residual solvent checks

COAs are sourced from independent certified labs rather than in-house testing alone, giving researchers a verifiable record of molecular integrity for each batch. All compounds are supplied for research use only.

Review the COAs for this batch below, or browse the full COA library.

Epithalon (261474)

Epithalon (261474)

Epithalon (260821)

Epithalon (260821)

Epithalon (12097)

Epithalon (12097)

Epithalon (260259)

Epithalon (260259)

Ephitalon(10920)

Ephitalon(10920)

Epithalon (2502050023)

Epithalon (2502050023)

Browse our full peptide catalog featuring research compounds for a wide range of scientific applications:

99%+ Purity, Third Party Tested

Independently verified by three separate certified laboratories. COAs available pre-purchase.

GMP Manufacturing Standards

Synthesized in USA-registered facilities following Good Manufacturing Practices. Full chain of custody documentation.

Best In Class Fulfillment

Same-day shipping on orders before 12 PM PT. Free standard domestic shipping on orders over $400.

Zero Fillers or Additives

Pure active compounds only. Independently verified composition for reliable in vitro studies.

Scientific Reviewer

Scientifically reviewed by Dr. Ky H. Le, MD. Dr. Le is a board-certified family medicine physician with over 20 years of clinical experience. Dr. Le validates the scientific accuracy of all technical content and research citations.

Disclaimer: For Research Purposes Only

This content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions about specific peptides and their researched benefits, is presented for informational purposes only and must not be construed as health, clinical, or legal guidance, nor an encouragement for non-research use. Peptides described here are solely for use in structured scientific study by authorized individuals. We advise consulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining or utilizing these peptides. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research peptides.
Glass vial with standard cap labeled Epithalon 20MG 99% Purity from Biolongevity Labs.Epithalon (20mg)
$94.97

Availability: In stock

- +

Don't forget your BAC Water

Glass vial of Biolongevity Labs Reconstitution Solution, 30ml, containing deionized pure water and .9% benzyl alcohol, made in the USA.
Reconstitution Solution (30ml) (BAC Water)
$19.97