PEG-MGF Product Description
PEG MGF (Pegylated Mechano Growth Factor) is a synthetic, modified form of MGF, which is a split variant of Insulin-like Growth Factor-1 (IGF-1). Through a process called pegylation, a polyethylene glycol (PEG) molecule is attached to the MGF peptide, significantly enhancing its stability for research use.
This peptide preferentially targets recently stressed or damaged muscle cell tissue, making it particularly suited for laboratory studies investigating muscle growth, repair and recovery.
Peptide Information
| Property |
Value |
| Peptide Sequence |
PEG-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys |
| Molecular Formula |
C121H200N42O39 |
| Molecular Weight |
2900 g/mol |
| CAS Number |
108174-48-7 |
| PubChem CID |
178101669 |
| Synonyms |
IGF-1 Ec E-peptide, MGF-E, Pegylated MGF, PEG-MGF-Ct24E, PEG Myotrophin |
Lyophilized Peptides:
These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage. We do not use any fillers in this process.
PEG MGF Research
PEG-MGF demonstrates significant potential across multiple regenerative applications. The research explores its effectiveness in muscle repair and regeneration, bone and cartilage healing, stem cell regulation and protective effects in both neural and cardiac tissues.
Musculoskeletal Regeneration and Muscle Repair
MGF has been shown to enhance satellite cell activation, proliferation, and fusion in human muscle progenitor cells. The peptide can delay cellular senescence and improve muscle repair, suggesting potential for combating age-related muscle loss and improving myogenic precursor cell transplantation outcomes in conditions like Duchenne muscularย dystrophy.[1]
Bone and Cartilage Repair
MGF promotes osteoblast proliferation, differentiation, and mineralization, and significantly enhance bone defect healing in animalย models.[2]
In cartilage repair, MGF combined with TGF-ฮฒ3 in silk fibroin scaffolds increases stem cell recruitment and chondrogenic differentiation, leading to improved articular cartilage regeneration and integration in rabbitย models.[3]
Stem Cell Migration and Differentiation
MGF E peptides regulate the migration and differentiation of bone marrow mesenchymal stem cells (BMSCs). While they do not affect BMSC proliferation, they enhance migration and shift differentiation toward adipogenesis over osteogenesis, mediated via the IGF1 receptor and Erk1/2 signalingย pathway.[4]
Neuroprotection and Cardiac Repair
The C-terminal peptide of MGF demonstrates strong neuroprotective effects in models of brain ischemia, functioning independently of the IGF-1 receptor and providing prolonged neuronal protection compared to full-lengthย IGF-1.[5] In cardiac tissue, localized delivery of the MGF E-domain peptide via polymeric microstructures after myocardial infarction improves cardiac function, reduces mortality, and prevents adverseย remodeling.[6]
References
- Kandalla, P., Goldspink, G., Butler-Browne, G., & Mouly, V. (2011). Mechano Growth Factor E peptide (MGF-E), derived from an isoform of IGF-1, activates human muscle progenitor cells and induces an increase in their fusion potential at different ages.ย Mechanisms of Ageing and Development, 132, 154-162.ย https://doi.org/10.1016/j.mad.2011.02.007.
- Wei, W., Liu, S., Song, J., Feng, T., Yang, R., Cheng, Y., Li, H., & Hao, L. (2020). MGF-19E peptide promoted proliferation, differentiation and mineralization of MC3T3-E1 cell and promoted bone defect healing..ย Gene, 144703 .ย https://doi.org/10.1016/j.gene.2020.144703.
- Luo, Z., Jiang, L., Xu, Y., Li, H., Xu, W., Wu, S., Wang, Y., Tang, Z., Lv, Y., & Yang, L. (2015). Mechano growth factor (MGF) and transforming growth factor (TGF)-ฮฒ3 functionalized silk scaffolds enhance articular hyaline cartilage regeneration in rabbit model..ย Biomaterials, 52, 463-75 .ย https://doi.org/10.1016/j.biomaterials.2015.01.001.
- Cui, H., Yi, Q., Feng, J., Yang, L., & Tang, L. (2014). Mechano growth factor E peptide regulates migration and differentiation of bone marrow mesenchymal stem cells..ย Journal of molecular endocrinology, 52 2, 111-20 .ย https://doi.org/10.1530/JME-13-0157.
- Dลuลผniewska, J., Sarnowska, A., Berฤsewicz, M., Johnson, I., Srai, S., Ramesh, B., Goldspink, G., Gรณrecki, D., & Zabลocka, B. (2005). A strong neuroprotective effect of the autonomous Cโterminal peptide of IGFโ1 Ec (MGF) in brain ischemia.ย The FASEB Journal, 19.ย https://doi.org/10.1096/fj.05-3786fje.
- Peรฑa, J., Pinney, J., Ayala, P., Desai, T., & Goldspink, P. (2015). Localized delivery of mechano-growth factor E-domain peptide via polymeric microstructures improves cardiac function following myocardial infarction..ย Biomaterials, 46, 26-34 .ย https://doi.org/10.1016/j.biomaterials.2014.12.050.
