Ipamorelin 10mg is a synthetic pentapeptide (Aib-His-D-2Nal-D-Phe-Lys-NH₂) made by controlled peptide synthesis and characterized as a selective agonist of the ghrelin receptor, GHS-R1a. Each vial holds 10mg of lyophilized white powder, sealed for stable storage and accurate reconstitution at the bench. Laboratories use it to compare receptor selectivity across the secretagogue peptide family, to probe pituitary cell signaling in culture, and to study ghrelin receptor activity in isolated tissue preparations.
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Ipamorelin was first described in 1998 by a Novo Nordisk chemistry team, who arrived at it by removing the central Ala-Trp dipeptide from the GHRP-1 sequence [1]. The result is a five-residue chain with a C-terminal lysinamide, one residue shorter than the hexapeptide reference ligands GHRP-2 and GHRP-6.
Two unnatural residues shape its structure. Aib (2-aminoisobutyric acid) sits at the N-terminus, and D-2-naphthylalanine sits beside D-phenylalanine at the core. Its research designation, NNC 26-0161, still appears across the early literature.
What sets the compound apart in research models is a narrow receptor profile at GHS-R1a, the same receptor that binds the endogenous ligand ghrelin [1].
Store the lyophilized compound at -20°C, sealed and away from light.
After reconstitution, store at 2°C to 8°C and use promptly.
Maintain aseptic handling to preserve compound integrity.
Lyophilized Format
This compound ships in lyophilized (freeze-dried) form. Freeze-drying supports long-term storage stability and preserves compound integrity. No fillers are added.
Research Use Disclaimer
Ipamorelin is supplied for research use only. It is not a drug, food, cosmetic, or dietary supplement and has not been evaluated by the FDA. By purchasing, the buyer confirms the compound will be used solely for in vitro research.
Frequently Asked Questions
What Is Ipamorelin 10mg Used For in Research?
Ipamorelin 10mg is used in laboratory work on GHS-R1a receptor selectivity, pituitary cell signaling in culture, and ghrelin receptor activity in isolated tissue. It is supplied for in vitro research use only.
What Is the Amino Acid Sequence of Ipamorelin?
Ipamorelin has the sequence Aib-His-D-2Nal-D-Phe-Lys-NH₂, a five-residue peptide with a C-terminal amide. Its molecular formula is C₃₈H₄₉N₉O₅ and its molecular weight is 711.9 g/mol.
What Is the CAS Number for Ipamorelin?
The CAS number for Ipamorelin is 170851-70-4, and its PubChem CID is 9831659. It is also listed under the research designation NNC 26-0161.
How Should Ipamorelin 10mg Be Stored?
Ipamorelin 10mg should be kept at -20°C in its lyophilized form, sealed and protected from light. Once reconstituted, it should be held at 2°C to 8°C and used promptly.
How Is the Purity of Ipamorelin Verified?
BioLongevity Labs verifies Ipamorelin at ≥99% purity through third-party HPLC testing. A Certificate of Analysis is available to review before purchase.
Ipamorelin Research
Ipamorelin is a selective growth hormone secretagogue that has been studied extensively for its unique receptor binding properties and physiological mechanisms in laboratory settings.
Growth Hormone Receptor Interactions
Ipamorelin operates through selective binding to ghrelin receptors, triggering pulsatile growth hormone release that mirrors natural secretion patterns[1]. The peptide’s molecular structure allows specific receptor activation without cross-reactivity across other hormonal pathways.
Studies show ipamorelin stimulates GH release while leaving ACTH, cortisol, prolactin, and thyroid hormones unaffected[1]. This selectivity makes it valuable for controlled laboratory experiments examining isolated growth hormone effects.
Skeletal Research Applications
Laboratory studies examining bone tissue demonstrate ipamorelin’s effects on bone mineral content and dimensional growth. Research indicates the peptide influences periosteal bone formation through growth hormone-mediated pathways[2].
In controlled settings, ipamorelin counteracted glucocorticoid-induced bone degradation by activating formation pathways. These findings support research into bone remodeling mechanisms at the cellular level[3].
Metabolic Pathway Studies
Growth hormone released through ipamorelin activation influences lipolytic pathways in adipose tissue. Laboratory analyses show increased free fatty acid circulation and altered glucose metabolism patterns[4].
Research examining insulin sensitivity pathways reveals complex interactions between GH signaling and metabolic regulation. These mechanisms remain areas of active in vitro investigation.
Cellular Repair Mechanisms
Studies exploring tissue regeneration hint at ipamorelin’s potential role in collagen synthesis pathways. The growth hormone-IGF-1 axis activated by the peptide appears to influence cellular proliferation and protein synthesis[5].
Laboratory work shows angiogenic pathway activation and enhanced tissue remodeling processes. These mechanisms support research into cellular recovery and regeneration at the molecular level.
Gastrointestinal Research
Laboratory studies have investigated Ipamorelin‘s interaction with ghrelinreceptors on cholinergic neurons and gastric emptying patterns. Research explores this through examining gastric smooth muscle contractility. Preclinical models studying post-surgical dysmotilityhave examined contractile responses through these enteric pathways in experimental settings[6].
References
[1] K. Raun et al., “Ipamorelin, the first selective growth hormone secretagogue,” Oxford University Press (OUP), Nov. 1998. doi: 10.1530/eje.0.1390552. https://doi.org/10.1530/eje.0.1390552
[2] J. Svensson et al., “The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats,” Bioscientifica, Jun. 2000. doi: 10.1677/joe.0.1650569. https://doi.org/10.1677/joe.0.1650569
[3] N. B. Andersen, K. Malmlöf, P. B. Johansen, T. T. Andreassen, G. Ørtoft, and H. Oxlund, “The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats,” Elsevier BV, Oct. 2001. doi: 10.1054/ghir.2001.0239. https://doi.org/10.1054/ghir.2001.0239
[4] S.-H. Kim and M.-J. Park, “Effects of growth hormone on glucose metabolism and insulin resistance in human,” Korean Society of Pediatric Endocrinology, Sep. 2017. doi: 10.6065/apem.2017.22.3.145. https://doi.org/10.6065/apem.2017.22.3.145
[5] D. K. Sinha et al., “Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males,” AME Publishing Company, Mar. 2020. doi: 10.21037/tau.2019.11.30. https://doi.org/10.21037/tau.2019.11.30
[6] B. Greenwood-Van Meerveld, K. Tyler, E. Mohammadi, and C. Peitra, “Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus,” Informa UK Limited, Oct. 2012. doi: 10.2147/jep.s35396. https://doi.org/10.2147/jep.s35396
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Scientifically reviewed by Dr. Ky H. Le, MD. Dr. Le is a board-certified family medicine physician with over 20 years of clinical experience. Dr. Le validates the scientific accuracy of all technical content and research citations.
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