NAD+ / MOTS-c / 5-Amino-1MQ Peptide Blend Description
The BioLongevity Labs NAD+/MOTS-c/5-Amino-1MQ Blend unites three distinct compounds that converge on cellular energy, mitochondrial function, and metabolic regulation:
- NAD+ (100 mg) replenishes the central redox cofactor required for metabolism, DNA repair, and sirtuin activation [1][2][3].
- MOTS-c (10 mg) is a mitochondria-derived peptide that activates AMPK, regulates nuclear gene expression under metabolic stress, and enhances insulin sensitivity [4][5][6].
- 5-Amino-1MQ (10 mg) inhibits NNMT, raising NAD+ levels while modulating histone methylation and fat metabolism pathways [7][8][9].
Together, their mechanisms are designed to:
- Enhance mitochondrial and cellular energy balance by restoring NAD+ pools and activating AMPK [1][4][7].
- Improve metabolic health by reducing adiposity, sustaining muscle function, and optimizing glucose regulation [2][5][8].
- Support cognitive and longevity research through effects on neuroinflammation, oxidative stress, and cellular senescence [3][6][9].
Peptide Structures
NAD+ (Nicotinamide Adenine Dinucleotide)
- Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
- Molecular Weight: 663.43 g/mol
- PubChem CID: 925
- CAS Number: 53-84-9
- Synonyms: β-Nicotinamide adenine dinucleotide, DPN, Coenzyme I, Diphosphopyridine nucleotide
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c)
- Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
- Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
- Molecular Weight: 2174.6 g/mol
- PubChem SID: 255386757
- CAS Number: 1627580-64-6
- Synonyms: Human MOTS-c, UNII-A5CV6JFB78, MOTS-c trifluoroacetate salt
5-Amino-1MQ (5-Amino-1-methylquinolinium)
- Molecular Formula: C₁₀H₁₁N₂
- Molecular Weight: 159.21 g/mol
- PubChem CID: 950107
- CAS Number: —
- Synonyms: 5-amino-1-methylquinolinium, SCHEMBL6403148, CHEMBL4116828, ZMJBCEIHNOWCMC-UHFFFAOYSA-O, STL196667
This synergistic triad provides a unique investigational platform for metabolism, neuroprotection, and healthy aging research.
Blend Structure
| Ingredient |
Dose (per capsule) |
Key Actions |
| NAD+ |
100 mg |
Cofactor in redox metabolism; activates sirtuins & AMPK; supports DNA repair & mitochondrial biogenesis [1][2][3] |
| MOTS-c |
10 mg |
Mitochondria-encoded peptide; AMPK activation; improves insulin sensitivity; prevents metabolic dysfunction [4][5][6] |
| 5-Amino-1MQ |
10 mg |
NNMT inhibitor; ↑NAD+; ↓adiposity; epigenetic modulation; metabolic & oncology research [7][8][9] |
Research Areas
- Cellular Energy & Mitochondrial Function
- Metabolic Regulation & Obesity Research
- Muscle Preservation & Physical Performance
- Neuroprotection & Cognitive Function
- Longevity & Anti-Aging Mechanisms
- Preclinical Cancer Research
NAD+/MOTS-c/5-Amino-1MQ Peptide Blend Research
Cellular Energy & Mitochondrial Function
NAD+ plays a vital role in redox reactions and sirtuin activation. Restoring NAD+ levels in aging and metabolic stress models improved glucose tolerance, mitochondrial function, and overall health [1]. MOTS-c translocates to the nucleus during metabolic stress to regulate antioxidant and glucose metabolism genes via AMPK activation [4]. 5-Amino-1MQ further boosts NAD+ by inhibiting NNMT, enhancing redox balance and mitochondrial efficiency [7].
Metabolic Regulation & Obesity Research
NAD+ depletion contributes to obesity and metabolic disorders; replenishment strategies improve metabolic homeostasis [2]. MOTS-c prevents diet-induced obesity and insulin resistance by improving glucose utilization and maintaining adipose homeostasis [5]. 5-Amino-1MQ reduces white adipose tissue and body weight in preclinical obesity models without affecting appetite, highlighting its direct metabolic actions [8].
Neuroprotection & Longevity
NAD+ enhancement has been shown to reduce neuroinflammation and improve cognition in models of neurodegeneration [3]. MOTS-c enhances memory formation and protects against neuroinflammation, with benefits observed in Alzheimer’s and metabolic dysfunction models [6]. 5-Amino-1MQ alters histone methylation and metabolic programs in cancer and aging models, representing a promising target for longevity and oncology research [9].
References
NAD+
- Rajman L, et al. Cell Metab. 2018. Therapeutic potential of NAD-boosting molecules in vivo. https://doi.org/10.1016/j.cmet.2018.02.011
- Okabe K, et al. J Biomed Sci. 2019. Altered NAD+ metabolism in metabolic disorders. https://doi.org/10.1186/s12929-019-0527-8
- Zhao Y, et al. J Neuroinflammation. 2021. NAD+ improves cognition via Sirt1/PGC-1α. https://doi.org/10.1186/s12974-021-02250-8
MOTS-c
- Kim K, et al. Cell Metab. 2018. MOTS-c translocates to the nucleus during metabolic stress. https://doi.org/10.1016/j.cmet.2018.06.008
- Lu H, et al. J Mol Med. 2019. MOTS-c regulates adipose homeostasis and prevents metabolic dysfunction. https://doi.org/10.1007/s00109-018-01738-w
- Lee C, et al. Cell Metab. 2015. MOTS-c promotes metabolic homeostasis and reduces obesity/insulin resistance. https://doi.org/10.1016/j.cmet.2015.02.009
5-Amino-1MQ
- Conlon N, Ford D. Biochem Pharmacol. 2022. Systems approach to NAD+ restoration via NNMT inhibition. https://doi.org/10.1016/j.bcp.2022.114946
- Liu J, et al. Biomed Res Int. 2021. NNMT inhibition reduces obesity and diabetes risk. https://doi.org/10.1155/2021/9924314
- Li X, et al. Front Oncol. 2022. NNMT as a biomarker and target in cancer. https://doi.org/10.3389/fonc.2022.894744
Note: This product is supplied strictly for investigational research use only.
